Abstract 16294: Atrial Fibrillation is Associated with Higher Percentage of Young Platelets
Introduction: Young platelets (YPlt) retain cytoplasmic mRNA and are capable of protein biosynthesis upon stimulation. Higher percentage of YPlt in patients with non-valvular atrial fibrillation (NVAF) may contribute to thromboembolic complications of this dysrhythmia.
Methods: To define the association with NVAF, flow cytometric quantification of YPlts was performed in NVAF patients before and 3 months after radiofrequency ablation (RFA; March -June 2009) compared to normal sinus rhythm (NSR) controls.
Results: Patients with NVAF (n=115; age 60±10; 28% female) had > 4 fold higher percentage of YPlt (28.5±7.2) compared to NSR controls (n=57; age 60±11; 33% female) (6.4±5.3; p<0.0001, Figure). Following RFA, YPlt percent dropped significantly (20.8±8; p<0.0001).
Conclusions: NVAF is associated with an enriched percentage of circulating YPlts. Within 3 months of sinus rhythm restoration, this percentage is reduced toward normal values. Rhythm disturbances impact the circulating percentage of YPlts which may contribute to the thrombotic propensity of NVAF.
- © 2010 by American Heart Association, Inc.