Abstract 16274: Association Between Spontaneous Echocardiographic Contrast and CHADS2
Background: Spontaneous echo contrast (SEC) is associated with increased risk of left atrial appendage thrombus (LAAT) and stroke in non-valvular atrial fibrillation (NVAF). The relation between SEC and CHADS2, the most commonly used measure for stroke risk, is poorly defined.
Methods: The association between CHADS2 and SEC intensity/ LAAT development was assessed prospectively for 532 consecutive NVAF patients undergoing a TEE study (10/1/2007 - 9/30/2009).
Results: Analysis of NVAF patients (age 62±13 years; 25% women; 28% persistent AF and 17% permanent AF) revealed a clear association between degree of whole blood stasis and prevalence (%) of CHADS2 elements (Table) and overall score (Figure). A sizable minority of patients with either severe SEC or LAAT had low CHADS2 score (<2). CONCLUSSION. Despite an association between SEC intensity and CHADS2 score, a sizable proportion of NVAF patients with either severe SEC or LAAT will have low scores. Improved risk prediction algorithms are therefore needed for risk stratification of NVAF patients.
- © 2010 by American Heart Association, Inc.