Abstract 16267: Changes in Fibrinogen Levels Track Longitudinally with Changes in Traditional Cardiovascular Risk Factors from Young Adulthood to Middle Age: The Coronary Artery Risk Development in Young Adults Study
Introduction: Multiple cross-sectional studies have linked cardiovascular events and traditional cardiovascular risk factors (RFs) with higher plasma fibrinogen levels. However, longitudinal data linking incidence or progression of traditional RFs to changes in fibrinogen levels over time are lacking. In a baseline young, asymptomatic cohort, we sought to determine associations between changes in/incidence of traditional RFs and changes in fibrinogen levels over 13 years.
Methods: We included 2856 black and white CARDIA participants. Fibrinogen and traditional RFs were assessed at year 7 (1992–93; ages 25–37) and Year 20 examinations (2005–06). For both exams, fibrinogen was measured using automated nephelometry. Multiple linear regression was used to estimate mean changes in fibrinogen in relation to changes in traditional RFs.
Results: During the 13 years between exams, mean fibrinogen increased by 72 mg/dL (Pearson correlation [r] between both exams =0.58, p <0.001). There were significant gender interactions in the relationship between 13-year changes in traditional RFs and changes in fibrinogen levels. After multivariable adjustments (Table), decreasing HDL cholesterol and increasing BMI were significantly associated with increased fibrinogen levels in both men and women (both p <0.001 in either gender). The remaining RFs tracked longitudinally with fibrinogen levels in either men or women. BMI, higher age difference and incident smoking were the RFs significantly different between men and women in their relationship to increased fibrinogen levels over time.
Conclusions: In this baseline young cohort with relatively low prevalence of cardiovascular risk factors, fibrinogen levels increased with development of or adverse changes in most major traditional RFs over 13 years of follow-up. This suggests that fibrinogen levels and traditional RFs track longitudinally. The observed differences between men and women require further exploration.
- © 2010 by American Heart Association, Inc.