Abstract 16208: Longer Duration of Overweight/Obesity Associated with Higher Odds of Developing Hypertension or Dyslipidemia: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Background: Obesity is a key risk factor for development of hypertension (HTN) and dsylipidemia. Yet it is unclear if duration of obesity is related to these outcomes; studies of self-reported obesity duration do not show associations. We hypothesized that objectively measured years of overweight/obesity would be associated with increased odds of developing HTN or dyslipidemia.
Methods: Black and white adults in the CARDIA Study, a NHLBI-sponsored multi-center longitudinal study, measured height, weight, blood pressure (BP), and fasting lipids at 7 exams over 20 years. Baseline for this analysis is the Year 0 (Y0) exam for participants age 26–30 at Y0 and the Y5 exam for participants age 21–25 at Y0. Thus, all participants were age 26–30 at entry with 15 years follow-up (to age 41–45). In 1761 young adults who were normal weight at entry, years of overweight/obesity (BMI ≥25 kg/m2) were calculated and cases of HTN (BP>140/90 or use of BP meds) or dyslipidemia (HDL-C, in women <50 ng/dL/men <40 ng/dL; LDL-C ≥130 ng/dL; or triglycerides ≥200 ng/dL) were determined over 15 years. Those with prevalent disease at entry were excluded from analysis. Logistic regression was used to estimate the odds of developing HTN or dyslipidemia by age 41–45 for each year of overweight/obesity.
Results: By age 41–45, 13.2% and 32.1% of initially normal weight participants developed HTN or dyslipidemia, respectively. After multivariable adjustment, the odds of developing HTN or dyslipidemia increased by 10–15% for each year of overweight/obesity within each race/gender group (see Table).
Conclusions: Objectively-measured years of overweight/obesity are associated with increased odds of developing HTN or dyslipidemia by age 41–45 among young adults initially normal weight at age 26–30, independent of baseline BMI. These results suggest that onset of HTN and dyslipidemia during the transition to middle age might be successfully prevented by delaying onset of overweight/obesity in young adults.
- © 2010 by American Heart Association, Inc.