Abstract 16055: Cardiovascular Sequelae in Long Term Survivors of Childhood Cancer.
Purpose: We aimed to examine incidence of cardiovascular sequelae within a cohort of long-term survivors of paediatric and adolescent cancer.
Method: Inpatient hospital admissions were linked to the Yorkshire Specialist Register of Cancer in Children and Young People. Eligible subjects were diagnosed with cancer aged >30 years between 1974–2005, and survived for at least five years. Cardiovascular sequelae were identified from diagnosis and procedures codes recorded in national hospital episode statistics (1996–2006). Patients with an event post-diagnosis were compared to those without. The likelihood of having an event was modeled using logistic regression adjusting for diagnostic group, sex, age, year of diagnosis, ethnicity and deprivation.
Results: A total of 1993 patients were included in the analysis, of which 7% (n=144) had a cardiovascular related hospital admission, 40% of which occurred exclusively post-diagnosis. We observed an excess of leukaemia (26.4%; n=38) and lymphoma (25.0%; n=36) in patients with cardiovascular episodes compared to those without (19.8% and 20.8% respectively). Cardiac episodes were 33% less likely amongst other solid tumours than haematological malignancies (OR=0.67; 95%CI 0.47–0.94). There was 5% less chance of a cardiac episode for every single year increase in year of diagnosis. Gender, age, ethnicity and deprivation were not significantly associated with cardiovascular sequelae in survivors. The five most common cardiac episodes observed post-diagnosis were essential hypertension (30%), complications and ill-defined descriptions of heart disease (10%), hypertensive renal disease (9.5%), cardiomyopathy (6.2%) and heart failure (5.5%).
Conclusion: Our data showed some indication of increased incidence of cardiovascular events amongst haematological malignancies compared to other tumours. Future work will involve expanding the study to include England as a whole, and will include outpatient hospital data with the aim of capturing a more comprehensive population of patients with cardiovascular sequelae.
- © 2010 by American Heart Association, Inc.