Abstract 16034: Sleep Duration and Carotid Intima-Media Thickness in the CARDIA Study
Background: Carotid intima-media thickness (IMT) is a subclinical measure of cardiovascular disease and serves as a preclinical marker of atherosclerosis. Recent studies suggest that shorter sleep duration is a risk factor for cardiovascular disease, but there is limited evidence regarding the underlying biological mechanisms.
Objectives: The objective of this study is to determine whether longer sleep duration is associated with lesser IMT.
Methods: The study used an observational cohort consisting of 617 black and white middle-aged (37–52 y; 58% female) healthy participants from the Coronary Artery Risk Development in Young Adults (CARDIA) ancillary sleep study. Multivariable-adjusted linear regression analyses were performed to evaluate this association. IMT was calculated using the average of 20 measurements of the mean common carotid, bulb and internal carotid IMT, which was assessed using high-resolution B-mode ultrasound images. Sleep duration was measured using wrist actigraphy monitors.
Results: The mean IMT among females and males was 0.68 mm (SD 0.12) and 0.74 mm (SD 0.13), respectively. Men slept less than women (5.7 h vs. 6.3 h, p<0.0001). Gender-specific regression analyses are highlighted in Table 1. After adjusting for covariates, one hour of longer sleep duration was associated with 0.021 mm lesser IMT among men (p=0.01, 95% CI −0.035, −0.006), and 0.002 mm lesser IMT among women (p=0.83, 95% CI −0.015, 0.012).
Conclusions: In summary, shorter objectively measured sleep duration was associated with greater carotid IMT among men but not women. These findings provide novel evidence of potential underlying biological mechanisms, and suggest that sleep duration may be an important risk factor associated with carotid IMT in men.
- © 2010 by American Heart Association, Inc.