Abstract 159: Improvement of Ventricular Fibrillation Threshold in Rats With Myocardial Infarction Treated With Cardiac Stem Cells
Objective:Arrhythmia is of concern after CSCs transplantation in repairing infarcted myocardium. However, whether transplanted CSCs improved Ventricular fibrillation threshold (VFT) in the myocardial infarction model, are still unclear.
Hypothesis: Ventricular fibrillation threshold (VFT) would be improved in myocardial infarction rats treated with CSCs.
Methods: Myocardial infarction was induced by ligation of the left anterior descending artery in 20 rats. Two weeks later, animals were randomized to receive of 5×106 CSCs labeled with PKH26 in phosphate buffer solution (PBS) or PBS alone injection into the infarction zone in the anterior ventricular free wall. 6 weeks after CSCs or PBS injection, VFT was measured in the infarct area, the infarct marginal zone and the non-infarct zone.
Results: In CSCs treated group, there were significant improvements in VFT in the infarct area, the infarct marginal zone and the non-infarct zone compared with the PBS treated groups (Table 1).
Conclusions: CSCs can improve the VFT in rats with myocardial infarction treated with allogenic CSCs.
- © 2010 by American Heart Association, Inc.