Abstract 15867: Myeloperoxidase Predicts Coronary Heart Disease Independently of Traditional Risk Factors, Inflammatory Markers and Markers of Endothelial Dysfunction: Results from the MONICA/KORA Augsburg Study
Background: Oxidative stress plays a critical role in the initiation and progression of atherosclerosis. Myeloperoxidase (MPO) is a marker of oxidative stress. We prospectively investigated whether increased serum concentrations of MPO are associated with an increased risk of incident coronary heart disease (CHD).
Methods: We conducted a population-based case-cohort study in middle-aged, healthy men and women within the MONICA/KORA Augsburg studies. Serum levels of MPO were measured in 333 case subjects with incident CHD at baseline and 1,728 non-case subjects healthy men and women. Mean follow-up was 10.8 ± 4.6 years.
Results: Baseline concentrations of MPO were higher in cases compared to noncases (p<0.001 in men, p=0.131 in women). After adjustment for various confounders, including major cardiovascular risk factors, inflammatory markers, and markers of endothelial dysfunction, the hazard ratio (HR) and 95% confidence interval (CI) comparing tertile extremes was 1.43 (95% CI, 1.02–2.01). There were no significant interactions of MPO with sex and overweight.
Conclusions: Elevated concentrations of the oxidative stress marker MPO were independently associated with increased risk for incident CHD and deserve detailed evaluation in further studies.
- © 2010 by American Heart Association, Inc.