Abstract 15739: Impact of Sleep Apnea Syndrome on Long-term Outcome in Patients with Acute Coronary Syndrome
Purpose: Sleep apnea syndrome (SAS) is very common risk factor for cardiovascular events. However, the impact of SAS on long-term outcome in patients with acute coronary syndrome (ACS) has not been fully evaluated.
Methods: We performed an overnight sleep study in 225 patients with ACS who were successfully treated with percutaneous coronary intervention between March 2004 and December 2007. Patients with an apnea-hypopnea index≥15/hour were considered to have SAS. We defined major adverse cardiovascular events (MACE) as cardiovascular death, non-fetal myocardial infarction, stroke and admission for congestive heart failure. Patients were followed for a mean period of 1227 days.
Results: Comorbidity of SAS with ACS was found in 56 patients (24.9%). MACE-free survival rate was significantly lower in patients with SAS (61.3% vs. 73.9%, p=0.033).
Conclusions: Our study showed a high prevalence of SAS among patients with ACS and SAS appeared to be a valuable predictor for clinical outcome in them. This suggests that earlier diagnosis and intervention for SAS should be considered in patients with ACS.
- © 2010 by American Heart Association, Inc.