Abstract 15676: Electrocardiographic risk factors for complete atrioventricular block: The Niigata Preventive Medicine Study
Background: Cardiac conduction disease is often progressive and requires pacemaker implantation at advanced stages. However, the predictive ability of electrocardiographic abnormalities for pacemaker is not well investigated.
Methods and Results: This prospective, community-based, observational cohort study was based on annual health examinations. We studied the association of electrocardiographic abnormalities with the risk of development of complete atrioventricular block. Participants with complete atrioventricular block at baseline were excluded. A total of 180,152 participants (age, 59 ± years; 122,457 women) were included in this study. During a follow-up of 8.8 ± 4.4 years, 127 participants (0.07%) developed complete atrioventricular block. In multivariate models, male gender, age, first-degree atrioventricular block, second-degree atrioventricular block, left bundle branch block, electrocardiographic left ventricular hypertrophy, and atrial fibrillation, but not right bundle branch block, were associated with development of complete atrioventricular block (Table). The risk of complete atrioventricular block increased across atrioventricular block degree. To address the possibility that these results were driven by cardiovascular disease, a strong risk factor for atrioventricular block, we conducted further analyses in 137,318 participants without baseline heart disease, treated hypertension, left ventricular hypertrophy, and atrial fibrillation. In multivariate models, first-degree atrioventricular block, second-degree atrioventricular block, and left bundle branch block remained risk factors for development of complete atrioventricular block.
Conclusions: We identified electrocardiographic risk factors and the predictive abilities for the development of complete atrioventricular block in general population. Our findings indicate that individuals with such risk factors require careful follow-up.
- © 2010 by American Heart Association, Inc.