Abstract 15613: Severity of Coronary Artery Disease Affects Not Only the Major Adverse Cardiac Events, but the Amputation in Patients with Peripheral Artery Disease
Background: One half of the patients with peripheral artery disease (PAD) have concomitant coronary artery disease (CAD), which may seriously affect the prognosis in these patients. However, whether the severity of CAD affects the major adverse cardiac events (MACE) and the amputation of the lower extremity in patients with PAD is still unclear.
Methods: In this retrospective, multicenter study, we analyzed 455 patients with PAD (70±9 years, male 74 %) undergoing endovascular therapy (EVT) and coronary angiography (CAG) from April 2002 to February 2009. CAG was performed before EVT. We classified the patients into 2 groups based on CAG: 0–1 vessel CAD and 2–3 vessel CAD. We evaluated the outcome (MACE and amputation) by log-rank test.
Results: 0–1 vessel CAD comprised 266 patients (58%). Diabetes mellitus and critical limb ischemia were found in 57% and in 25% of all patients, respectively. The mean duration of follow up was 933±476 days. Both the freedom from MACE and the amputation of the lower extremity were higher in 0–1 vessel CAD than in 2–3 vessel CAD (MACE: 91% versus 87%, P=0.017; amputation: 95% versus 89%, P=0.020).
Conclusions: Severity of coronary artery disease affected not only the major adverse cardiac events, but the amputation of the lower extremity in patients with peripheral artery disease.
- © 2010 by American Heart Association, Inc.