Abstract 15598: Childhood Overweight affects Vascular and Left Ventricular Myocardial Structure and Function.
Introduction: Although changes in vascular and myocardial structure and function are present in overweight children, few studies have examined the blood vessels and the heart simultaneously. We sought to investigate vascular and myocardial structure and function in overweight children. We hypothesized that changes in myocardial structure and function are associated with vascular changes.
Methods: Nineteen overweight (BMI ≥ 85th %) and 27 normal weight control subjects aged 14±2 years participated. Ventricular assessment included M-mode, B-mode, and color tissue Doppler (CTD) echocardiography. Images were analyzed off-line using EchoPAC (GE, USA) for speckle tracking echocardiography (STE) and SPEQLE (University of Leuven, Belgium) for CTD echocardiography to assess LV radial and circumferential systolic strain (ε) and longitudinal systolic ε and strain rate (SR). Vascular assessment included carotid intima media thickness (CIMT), pulse wave velocity (PWV) and flow mediated dilatation (FMD). Differences between groups were assessed using the independent sample t-test and associations using Pearson correlation analysis.
Results:Systolic blood pressure, resting heart rate, LV mass, PWV and CIMT were higher and various myocardial deformation parameters were lower in overweight compared with controls (table). Ejection fraction, circumferential ε and FMD were similar. CIMT was associated with mean longitudinal ε (R = 0.48, p = 0.04) and diastolic SR (R = −0.59, p < 0.01). No other associations between vascular and myocardial parameters were found.
Conclusion:Reduced myocardial deformation parameters, increased CIMT and PWV were noted in overweight children. This suggests the early presence in overweight children of sub-clinical reductions in systolic and diastolic function, vascular geometric changes and increased arterial stiffness. Associations between vascular and myocardial parameters can be shown and warrant further investigation.
- © 2010 by American Heart Association, Inc.