Abstract 15446: Impact of Metabolic Syndrome on the Characteristics of Coronary Plaques Using Computed Tomography Angiography
Metabolic syndrome (MetS) is associated with the increasing risk of cardiovascular disease. The computed tomography (CT) characteristics of positive vessel remodeling (PR) and low-attenuation plaques (LAP) were at a higher risk of acute coronary syndrome. We assessed the impact of MetS on the characteristics of coronary plaques using 64-slice CT angiography.
Methods: Four hundred twelve patients with suspected coronary artery disease (CAD) underwent 64-slice CT angiography. The plaque characteristics and CT density value were analyzed on CT. Vulnerable plaque was defined as positive vessel remodeling (PR) and low-attenuation plaques (LAP) (<50 Hounsfield Unites) on CT. We defined MetS criteria by the modified Japanese criteria with cutoff point of waist circumference that was 90cm in men and 85cm in women.
Results: The prevalence of MetS was 164 patients (40%) among 412 patients. The number of coronary plaques per patient (4.7 ± 1.8 vs 1.7 ± 1.6, p<0.0001) and vulnerable plaques (1.1 ± 1.0 vs 0.16 ± 0.42, p<0.0001) were significantly higher in patients with MetS than in those without. In addition, the patients with MetS had higher prevalence of vulnerable plaque (60% vs.14%, p<0.0001), and the vulnerable plaque rate was significantly associated with an increasing number of MetS components in the grouping (p =0.003). (Figure)
Conclusion: Metabolic syndrome is associated with positive vessel remodeling (PR) and low-attenuation plaques (LAP) on CT, contributing to the increasing risk of plaque vulnerability.
- © 2010 by American Heart Association, Inc.