Abstract 154: Comparison Carvedilol With Bisoprolol on Mortality and Inflammatory Responses to Endotoxin-Induced Shock in Rats
Background: Recent studies showed that beta-blockers are widely used in hypertensive and/or cardiac failure patients because of its drug efficacy. Moreover, several studies showed that beta-blockers suppress the LPS-induced production of cytokine and tissue factor in vitro and attenuate myocardial dysfunction in septic animals. However, there are few studies about the effects of oral administration of beta-blocker during sepsis. The current study was to evaluate and compare the effects of oral administration of beta-blockers (carvedilol and bisoprolol) to endotoxin-induced shock in rats.
Methods: Thirty-six male Sprague Dawley rats were randomly assigned to one of the following three groups (n = 12 per group): control group, no medication; carvedilol group, oral administration of carvedilol (10 mg/kg/day) for 5 days; bisoprolol group, oral administration of bisoprolol (2 mg/kg/day) for 5 days. After then, all animals were anesthetized with pentobarbital ip. Endotoxin-induced shock was induced by 15mg of endotoxin iv. There were no other therapies before, during or after shock. Hemodynamics and arterial blood gases were recorded, and mortality were calculated for the 8-hr observation period and plasma cytokine concentrations were measured at 5-hr after shock.
Results: The mortality rates at 8hrs after endotoxin injection were 17 %, 75 %, and 33 % for control, carvedilol and bisoprolol groups, respectively. The mortality rate in the carvedilol group was significantly higher than those in the control and bisoprolol groups. The increases in base deficit and lactate concentrations were higher in the carvedilol group than the control and bisoprolol groups.
Conclusion: The present study showed that oral administration of carvedilol had the disadvantage effects on mortality and inflammatory responses to endotoxin-induced shock in rats.
- © 2010 by American Heart Association, Inc.