Abstract 15396: Low Levels of Adiponectin Predict the Progression of Arterial Stiffness in Patients With Hypertension
Background: Recent studies suggest that adiposity is associated with arterial stiffness. However, it is unclear which adipokine is related with the progression of arterial stiffness. We hypothesized that in hypertensive patients, initial low levels of adiponectin are related to the progression of arterial stiffness, which has been proven to be associated with increased risk of cardiovascular events.
Methods: One hundred forty six consecutive patients with treated essential hypertension (62 men, 57.7±8.2 years) were enrolled. Pulse wave velocity (PWV) was measured at baseline, and after 24 months. Clinical variables and laboratory findings including plasma adiponectin levels were analyzed at the time of initial enrollment.
Results: Mean heart to femoral PWV (hfPWV) was 993±204 cm/s at baseline, and 1019±264 cm/s at 24 months follow up. hfPWV progressed in seventy two patients (49.3%) during follow up period. In patients with hfPWV progression, mean plasma adiponectin level was significantly lower than patients with non progression (progressor: 5.18±3.21 μg/ml, non-progressor: 7.02±5.19 μg/ml, p=0.013). Multivariate regression analysis revealed plasma adiponectin level to being an independent predictor of hfPWV changes (β=−0.195, p=0.021) when controlled for age, gender, SBP changes and HOMA.
Conclusions: Plasma adiponectin level could be applied as an easy and reliable indicator of the progression of arterial stiffness in hypertensive patients. These findings may explain the high association between adiposity and arterial stiffness.
- © 2010 by American Heart Association, Inc.