Abstract 15002: 18F-Fluorodeoxyglucose Uptake with Positron Emission Tomography/Computed Tomography at Common Carotid Artery is a Strong Predictor of Acute Coronary Syndrome
Background: Inflammation plays an important role in outcome of atherosclerosis and it affects not only local but systemic vascular atherosclerosis. We investigated 18F-fluorodeoxyglucose (FDG) uptake with Positron Emission Tomography/Computed Tomography (PET/CT) at common carotid artery (CCA) to detect whether carotid inflammation predicts the systemic vascular inflammation in acute coronary syndrome (ACS).
Methods: This study included 48 consecutive subjects with ACS (ACS group: 25 single vessel disease (SVD), 23 multi vessel disease (MVD)) and 43 subjects matched for clinical parameters who performed voluntary cancer screening by FDG-PET/CT imaging (control group). All subjects were measured the maximum and mean standard uptake value (SUV) at CCA with FDG-PET/CT. Vascular inflammation in CCA was determined as the ratio of carotid SUV to blood activity (arterial tissue-to-background ratio, TBR).
Results: The maximum and mean TBR of CCA in ACS group were significantly higher than its in control group. Moreover the maximum and mean TBR of CCA in MVD group were significantly higher than its in SVD group. See table and picture.
Conclusions: In this study, active inflammatory atherosclerosis spread beyond the coronary artery and FDG-PET/CT could detect the systemic concealed vascular inflammation in ACS. FDG uptake of CCA was a more sensitive predictor for vascular inflammation in comparison to high-sensitivity C-reactive protein.
- © 2010 by American Heart Association, Inc.