Abstract 14938: Atorvastatin Treatment Improves Endothelial Function and Reduces Low-Grade Inflammation in Patients With Successfully Repaired Coarctation of the Aorta: A Cross Over Study
Background: Coarctation of the aorta is a congenital condition characterized by aorta stenosis. Subjects with successfully repaired coarctation of the aorta (SCR) experience higher long term cardiovascular risk as a result of the higher incidence of arterial hypertension. These subjects also experience endothelial dysfunction in the right forearm and appear to have elevated levels of proinflammatory markers. The aim of our study is to evaluate the effect of atorvastatin on endothelial function and inflammatory marker levels in a group of subjects with SCR.
Methods: We studied 19 normocholesterolemic and normotensive individuals age 31.1+/- 10.8 years old with SCR, received atorvastatin 10mg/day for 4 weeks in a randomized, cross over, controlled diet. Endothelial function was evaluated in the right forearm by flow-mediated dilation (FMD), whereas serum levels of interleukin-1b (IL-1b), IL-6 and soluble vascular cell adhesion molecule (sVCAM)- 1 were determined by enzyme-liked immunosorbent assay.
Results: Atorvastatin significantly improved endothelial function (p<0.01, fig.A). Furthermore atorvastatin decreased the expression of proinflammatory cytokine IL-1b and IL-6 (p<0.05, fig. B and C) and decreased serum levels of sVCAM-1 (p<0.05, figD)
Conclusions: Atorvastatin treatment reversed the impaired endothelial function, while also exhibited a beneficial effect on proinflammatory cytokines by decreasing the expression of IL-1b, IL-6 as well as of sVCAM-1, in subjects with SCR. These data revealed one additional pleiotropic action of atorvastatin, indicating a potent anti-inflammatory and anti-atherogenic effect in patients with SCR.
- © 2010 by American Heart Association, Inc.