Abstract 14631: Peripheral Vascular Compliance, Metabolic Syndrome, and Framingham Risk Score: Associations in Older Adults (The Rancho Bernardo Study)
Objective: Examine the association between the Framingham Risk Score (FRS), metabolic syndrome (MetS), and peripheral vascular compliance (PVC).
Background: PVC measured by arterial distensibility has been associated with the development and progression of cardiovascular disease.
Methods: Participants of the Rancho Bernardo Study (n=833) who had PVC and cardiovascular risk factors assessed at a clinic visit (1997-1999) were included in this analysis. PVC was assessed using measurements of brachial oscillometric pressures and categorized as normal/abnormal; MetS was defined by ATP-III; FRS for 10-year risk greater than 20% was considered high risk.
Results: Participants were 329 men and 504 women aged 75.2±8.4 years. Compared with participants with normal PVC, participants with abnormal PVC were older and had higher systolic blood pressure (158±18 mm Hg vs. 132±17 mm Hg, p<0.001) and higher pulse pressure (85±18 mm Hg vs. 58±15 mm Hg, p<0.001). Prevalence of MetS was 26.0% in participants with abnormal PVC and 13.0% in those with normal PVC (p <0.001). The proportion of participants with FRS >20% was greater among those with abnormal than normal PVC (26.3% vs. 15.3% p=0.003). In multivariate analysis adjusted for age and sex (for MetS), both MetS and FRS>20% were associated with abnormal PVC (OR 2.76; 95%CI 1.7-4.54, p < 0.001 and OR 1.94 95%CI 1.22-3.08, p=0.005, respectively).
Conclusion: Reduced peripheral vascular compliance is significantly associated with both MetS and FRS. The current study supports the evidence for an association of PVC with well-established predictors of vascular disease.
- © 2010 by American Heart Association, Inc.