Abstract 14482: Tricuspid Annular Plane Systolic Excursion Does Not Correlate with Right Ventricular Volumes or Function in Adults with Repaired Tetralogy of Fallot
Introduction: Tricuspid annular plane systolic excursion (TAPSE) correlates reasonably well with right ventricular (RV) function in patients with structurally normal hearts and has been validated in diverse pathophysiologic states. Its applicability for patients with repaired Tetralogy of Fallot (TOF), who often have residual pulmonary regurgitation and an RV outflow tract patch, has been questioned.
Methods: We quantified 2D echocardiographic TAPSE (mean TAPSE for 3 beats) in 39 adult patients with repaired TOF and analyzed the relationship of this simple marker to MRI-derived RV volumes, systolic function, and pulmonary regurgitant fraction obtained within 14 months of the echocardiogram.
Results: The mean age of the study population was 34.1 ± 10.6 years and 56.1% were male (Table). There were 22 patients with TAPSE <1.8cm, a finding correlated with RV dysfunction in other populations, and 19 with TAPSE >1.8cm. RV ejection fraction estimated by MRI did not significantly differ between the high and low TAPSE groups, 42.4 ± 10.6 and 43.0 ± 10.7%, respectively (p=0.88). TAPSE group did not predict RV stroke volume, pulmonary regurgitant fraction, or left ventricular ejection fraction (Table). There was no correlation of RV ejection fraction with TAPSE measurements when represented as a continuous variables, p= 0.46 (Figure).
Conclusions: TAPSE does not correlate with RV volumes or function in adults with repaired TOF, possibly due to surgical patch correction causing regional wall motion abnormalities not reflected in measurement of longitudinal RV free wall movement.
- © 2010 by American Heart Association, Inc.