Abstract 14432: Selective Serotonin Reuptake Inhibitors Exert a Negative Effect On Peripheral Wave Reflections
Introduction: In view of the high likelihood that hypertensives will have comorbid anxiety and depression, all hypertensives should be screened for concurrent psychiatric illnesses and treatment.
Hypothesis: We hypothesised that there is a relationship between the administration of selective serotonin reuptake inhibitors (SSRIs) and arterial stiffness, a hallmark of the cardiovascular ageing process.
Methods: We studied 210 consecutive untreated stage I-II essential hypertensive subjects (aged=62±9 years, 110 female, office blood pressure (BP) = 163/91 mm Hg). The participants were divided into group A (n=83), those receiving SSRIs and group B (n=127), those without taking any antidepressant therapy. Arterial stiffness was evaluated on the basis of carotid to femoral pulse wave velocity (c-f PWV) by means of a computerized method (Complior SP). Venous blood sampling was performed for the estimation of routine metabolic profile.
Results: The two groups did not differ regarding age, gender, office systolic/diastolic BP as well as serum glucose and triglycerides levels (83±9 vs 84± mg/dl and 128±8 vs 119±9 mg/dl, respectively, p=NS in all cases). Group A was characterized by increased levels of body mass index (32.4±3 vs 29.2±4 kg/m2, p=0.015) and elevated cholesterol plasma levels compared to group B (231±32 vs 220±36 mg/dl p<0.05). Group A compared to group B exhibited significantly increased c-f PWV (8.4±0.3 vs 7.2±0.5 m/sec, p=0.02) and this difference remained significant after adjustment for confounders (p=0.03). In the SSRIs treated- hypertensives, c-f PWV was correlated with age (r=+0.35, p= 0.015) and office systolic BP (r=+0.33, p= 0.02), while no significant correlation was demonstrated with cholesterol levels (p=NS).
Conclusions: In conclusion, the administration of SSRIs exerts an incremental effect on arterial stiffness, accelerating the vascular ageing process.
- © 2010 by American Heart Association, Inc.