Abstract 14282: Heart-type Fatty Acid Binding Protein as Predictor of Cardiac Mortality and Events in Patients with Acute Decompensated Heart Failure
Background: Heart-type Fatty Acid Binding Protein (H-FABP) revealed the presence of ongoing myocardial damage. They have been detected in heart failure and are associated with a bad prognosis. However its role in acute decompensated heart failure is unclear. We investigated the association between elevated H-FABP levels and adverse events in patients hospitalized for acute decompensated heart failure.
Methods and Results: We measured serum H-FABP level in 135 patients with acute decompensated heart failure. During a median 615 days, 69 patients had cardiac events (cardiac death and readmission for worsening heart failure). In multivariate Cox proportional analysis, the predictors of clinical events were age, H-FABP, and sodium. From the receiver operating characteristic curve analysis, the cutoff value of H-FABP level was determined as 5.7 ng/ml. Overall, 88 patients (65.2%) were positive for H-FABP. Patients with high H-FABP had higher in-hospital mortality than those with low H-FABP (6.7% vs. 0%, P<0.05). Kaplan-Meier analysis demonstrated that the high H-FABP group had significantly higher incidence of cardiac events compared with the low H-FABP group. We classified all patients with heart failure in 4 groups based on the quartile values of H-FABP. Interestingly, Kaplan-Meier analysis demonstrated that cardiac mortality and cardiac event rates were significantly lower in first quartile group than in other quartile groups (Figure).
Conclusion: In patients with acute decompensated heart failure, elevated H-FABP is associated with higher in-hospital mortality, and predicts cardiac mortality and events.
- © 2010 by American Heart Association, Inc.