Abstract 14181: Influence of Arterial Stiffness on Cerebral Microvascular Damage in Hypertensive Patients With Subclinical Atherosclerosis
Background: Arterial stiffening is associated with incidence of stroke and impairment of cognitive function; however there has been little information on the relationship between arterial stiffness and cerebral microvascular damage. Retinal arterioles provide important information on cerebral microvascular function noninvasively because retinal arterioles have similar characteristics to the cerebral arterioles. In this study, we evaluated the relationship between arterial stiffness and impairment of retinal arterioles in hypertensive patients.
Methods and results: We examined 70 hypertensive patients without history of atherosclerotic disease such as myocardial infarction, stroke and peripheral arterial disease. Pulse wave velocity (PWV), which is an index of arterial stiffness, was measured with form PWV/AVI (Colin/Omron, Japan). Retinal arterioles were evaluated with seven components including arteriolar constriction, arteriolar caliber irregularity, retinal hemorrhage, arteriovenous crossing, increase in light reflex, soft or hard exudates, and arterial silver wiring. The severity of retinal arterioles disease was determined according to the number of these components. Patients were classified into three groups according to the number of retinal arterioles abnormality: 0–1 (Group1, n=11), 2 (Group 2, n=32), 3–4 (Group3, n=27). Patients with higher number of retinal arterioles abnormality have higher PWV 13.7+/−2.0, 15.6+/−3.3, 18.2+/−3.3 m/sec, respectively, p=0.013) (Figure). In univariable analysis, number of retinal arterioles abnormality was significantly associated with PWV (r=0.46, p=0.0001). This significance was still held even after adjustment for age, gender, blood pressure, heart rate, HbA1c and BMI.
Conclusion: It is suggested that arterial stiffness is associated with cerebral microvascular damage assessed by retinal arterioles abnormalities independently of age, blood pressure and metabolic factors.
- © 2010 by American Heart Association, Inc.