Abstract 13912: Analysis of the Relation between Oxidative Stress Level and Thrombotic Risk Stratified by CHADS2 Score in Atrial Fibrillation
Background: Previous studies have suggested that there is a link between oxidative stress and atrial fibrillation (AF), and that oxidative stress may contribute to the pathological consequences of AF such as thrombosis and atrial tissue remodeling. However, little is known about the relationship between the oxidative stress level and thrombotic risk of AF.
Objectives: The purpose of this study was to investigate the possible association between the oxidative stress biomarker and thrombotic risk stratified by CHADS2 score in AF patients.
Methods: Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) is a product of oxidative DNA damage, and it is excreted in the urine. To determine the oxidative stress level, urinary 8-OHdG which is regarded as a putative biomarker of systemic oxidative DNA damage induced by reactive oxygen species was measured. Urinary 8-OHdG level was measured in 183 patients with sinus rhythm (SR group) and 117 patients with AF (AF group). The urinary 8-OHdG levels were corrected by the urinary concentration of creatinine. AF patients were further divided into three sub-groups according to the CHADS2 score (Group 0; CHADS2=0, Group 1; CHADS2=1, Group 2; CHADS2≥2). Urinary 8-OHdG/creatinine levels were compared among these sub-groups.
Results: The urinary 8-OHdG/creatinine levels of AF group was significantly higher than that of SR group (16.2±8.2 vs. 13.6±6.3 ng/mg, P<0.003). The 8-OHdG/creatinine level of Group 0, 1 and 2 were 12.5±7.2, 16.0±7.9 and 18.4±8.4 ng/mg, respectively. The 8-OHdG/creatinine level of Group 0 was significantly lower than that of Group 1 (p<0.05) and Group 2 (p=0.0003), respectively. However, there was no significant difference in the 8-OHdG/creatinine levels between Group 0 and SR group (12.5±7.2 vs. 13.6±6.3 ng/mg, P=NS). Thus, a close relation between 8-OHdG/creatinine levels and CHADS2 score was observed.
Conclusions: The oxidative stress level is elevated in AF. In particular, it is remarkable in the high thrombotic risk patients. The elevation of the oxidative stress level closely associated with the thrombotic risk of AF. These suggest that the oxidative stress may contribute to the pathologic process of thrombus formation in AF.
- © 2010 by American Heart Association, Inc.