Abstract 13761: Vitamin D Deficiency is Associated with Increased Cardiovascular Events: A Meta - Analysis of Prospective Studies
Background: Accumulating evidence suggests that vitamin D (VitD) deficiency is associated with worse cardiovascular outcomes. Hence, we conducted a meta-analysis of prospective studies assessing the relationship between VitD deficiency and cardiovascular events.
Methods: Relevant prospective studies assessing the relationship between VitD deficiency and adverse cardiovascular events (non-fatal and fatal) were identified by search of Medline and Web of Science to January 2010. Agency for Health Care Research and Quality (AHRQ) Critical Appraisal Criteria were used for study quality assessment. Only good or fair quality studies were included in the analysis.
Results: Seven studies met our selection criteria. The pooled relative risk (RR) for cardiovascular events in subjects with VitD deficiency was 1.67 (95% CI: 1.23 – 2.28; p = 0.001) during an average (weighted mean) follow up of 11.8 years. There was significant heterogeneity found across studies (Q statistic = 16.6 [6 d.f.], p = 0.01, I2 = 63.8%). Omitting two studies that contributed substantially to observed heterogeneity (new Q statistic 4.6, p=0.33, I2 = 12.9%) yielded a pooled RR of 1.34 (95% CI 1.08 –1.67; p=0.009). Results remained similar when analysis was restricted to good quality studies (RR 1.45, 95% CI 1.05–2.01, p=0.026), studies reporting cardiovascular mortality (RR 1.86, 95% CI 1.20– 2.87), or studies adjusting for seasonal variation in VitD levels (RR 1.68, 95% CI 1.17–2.40, p=0.005). There was no evidence of publication bias.
Conclusion: VitD deficiency is associated with increased risk of adverse cardiovascular events.
- © 2010 by American Heart Association, Inc.