Abstract 13730: Brain Callosal Fiber Injury is Localized in Patients with Heart Failure
Heart failure (HF) patients show cognitive, motor, and affective deficits. The corpus callosum (CC), which passes fibers from one hemisphere to the other, carries axons serving those functions. However, the extent of CC fiber integrity in HF is unclear; yet that integrity can be assessed by diffusion tensor imaging (DTI)-based fiber tractography procedures.
Methods: We collected four DTI series from 16 HF (age 55.1±7.8 years; BMI 29.6±5.8 kg/m2; 12 male; LVEF 28±7; 5 of ischemic etiology) and 25 control (age 49.4±10.9 years; BMI 26.0±3.7 kg/m2; 17 male) subjects using a 3.0-Tesla MRI scanner. DTI series were realigned, averaged, and whole-brain fiber tracks were calculated. Regional CC fiber counts were evaluated with fiber tractography procedures, including sites that project to prefrontal, premotor, sensory-motor, parietal, temporal, and occipital areas. Demographic data were assessed with independent samples t-tests and Chi-square, and regional CC fiber counts between groups were determined with ANCOVA (covariates; age and gender).
Results: No significant differences in age (p = 0.06) or gender (p = 0.63) emerged between the groups. BMI showed that HF subjects were significantly larger (heavier) than control subjects (p=0.04). Regional CC evaluation showed significantly reduced fiber counts in HF compared to control subjects in sites that project to temporal (HF vs controls; 272.7±75.9 vs 315.7±74.8, p = 0.03) and occipital areas (397.5±103.7 vs 471.1±77.9, p = 0.008). Fiber projections from the temporal and occipital CC areas are shown in a HF and age- and gender-matched control subject (Fig. 1). Other CC sites showed no significant differences between the groups.
Conclusion: Selective CC fibers in HF are reduced in sites that project to cognitive, motor, and emotion regulatory areas. Such site-specific fiber reduction may result from, and contribute to, characteristics found in the syndrome.
- © 2010 by American Heart Association, Inc.