Abstract 13560: Adverse Influence of Adiposity on Wave Reflection in Healthy Children
Background: The relationship between childhood obesity and adverse cardiovascular outcomes during adulthood may be mediated through the promotion of impaired vascular function. Wave reflection is an index of arterial function that is determined by arterial stiffness and is predictive of adverse cardiovascular events in adults. We evaluated the influence of adiposity on wave reflection in healthy children.
Methods: We examined 570 healthy children during 2007 (mean age 10.1±0.4, 50% boys). Adiposity was assessed by percentage body fat (%BF) quantitated by dual-energy x-ray absorptiometry. Insulin resistance was evaluated using a homeostasis model assessment (HOMA-IR). Cardiorespiratory fitness (CRF) was assessed using a 20-meter shuttle run. Radial artery wave reflection was assessed in using applanation tonometry (SphygmoCor, Atcor Medical, Sydney, Australia). The second peak of radial systolic blood pressure (SBP2) was obtained from the radial arterial waveform.
Results: In univariable analysis, body mass index (r=0.176), waist circumference (r=0.194) and %BF (r=0.232) were associated with radial SBP2 (all p<0.001). HOMA-IR (r=0.125, p=0.004) and CRF (r=−0.109, p=0.012) was also associated with radial SBP2. In multivariable analysis, %BF was associated with radial SBP2 after adjustment for age, sex, blood pressure, heart rate, height, HOMA-IR and CRF (Table).
Conclusion: Increased adiposity is related to greater wave reflection in healthy children, independently of blood pressure and heart rate. Further studies are required to evaluate whether public health efforts to promote healthy lifestyles and weight loss in children will attenuate the progression of subclinical cardiovascular disease, and prevent the development of subsequent cardiovascular events in the community.
- © 2010 by American Heart Association, Inc.