Abstract 134: Incidence of Acute Pancreatitis Among Out of Hospital Cardiac Arrest Survivors Treated in a Comprehensive Post-Resuscitation Program
Background: Previous studies have shown that therapeutic hypothermia (TH) improves neurologic outcome and reduces mortality in patients after out of hospital cardiac arrest (OHCA) and suggested the incidence of acute pancreatitis in this patient population is approximately 1%. The goal of this study was to determine the incidence of acute pancreatitis in OHCA patients who were treated in a comprehensive post-resuscitation program (CPRP).
Methods: Adult, non-traumatic, OHCA patients surviving to hospital admission and enrolled in a CPRP between March 1, 2004 and October 29, 2009 were included. Structured data was retrospectively collected including demographics, medical history, survival, serum lipase, and radiologic studies on presentation and during hospital course to determine the incidence of acute pancreatitis.
Results: Of the 136 patients included in the investigation, 60 (44.1%) survived to hospital discharge. There was no difference in mean age, sex, social or medical history. During the hospital course 29 (21.3%) patients were found to have elevated lipase (mean peak 166 units/L 95% CI 83.85 – 248.0) and 6 survived (20.6%). 25 (86.2%) of those with lipase elevation occurred within 24 hours of admission. Eight patients with elevated lipase received radiologic studies of which 3 (2.2%) confirmed acute pancreatitis. One patient with acute pancreatitis survived to discharge.
Conclusions: A CPRP has been shown to reduce morbidity and mortality in OHCA patients. The incidence of acute pancreatitis encountered by patients treated in a CPRP is about 2% and inline with previously published reports.
- © 2010 by American Heart Association, Inc.