Abstract 13330: High Epicardial Adipose Tissue Volume as a Predictor of Vulnerable Coronary Plaques using 64-slice Computed Tomography
Background: The relationship between epicardial adipose tissue (EAT), which has a metabolic activity, and coronary plaque vulnerability remains unclear. We investigated whether a high EAT volume is related to coronary plaque vulnerability as assessed by computed tomography (CT).
Methods and Results: We enrolled 317 consecutive patients (age: 66 ± 11 years: 64% male patients) who underwent 64-slice CT for coronary evaluation. The EAT volume was calculated as the sum of cross-sectional CT images used for calcium scoring from the atrial appendage to the apex. The presence of coronary low-density plaques (LDP: minimum CT density < 39 Hounsfield units) and positive remodeling (PR: remodeling index > 1.05) were used as an indicator for plaque vulnerability. Patients were divided into low and high EAT volume groups. The cut-off value was determined to be 106 ml which was the highest diagnostic accuracy to predict the presence of LDP with PR. After adjusting for traditional cardiovascular risk factors, a high EAT volume was found to be an independent predictor of positive LDP with PR (odds ratio [OR] 1.84, 95% confidence interval [CI] 1.09–3.14). In the subgroup analyses, a high EAT volume was an independent predictor in non-diabetic (OR 2.45, 95% CI 1.32–4.65) and non-obese (BMI < 25 kg/m2) patients (OR 2.22, 95% CI 1.21–4.13), but not in diabetic and obese patients.
Conclusions: A high EAT volume was associated with coronary plaque vulnerability, which was particularly present in non-diabetic and non-obese patients.
- © 2010 by American Heart Association, Inc.