Abstract 13226: Association between 25-hydroxyvitamin D levels and Metabolic Syndrome in Older Adults
Introduction: A limited number of cross-sectional studies show an association between 25-hydroxyvitamin D and metabolic syndrome (MetS). We explore the association of 25-hydroxyvitamin D levels with prevalent and incident MetS in a well-functioning cohort of older adults and hypothesize that 25-hydroxyvitamin D will be associated with MetS after adjusting for demographics, lifestyle factors, and renal function.
Methods: A total of 2,636 Health, Aging, and Body Composition (Health ABC) Study participants, with complete data on MetS, covariates of interest and 25-hydroxyvitamin D levels were examined at baseline (1997–1998). MetS status was defined using the ATP III guidelines. The association between 25-hydroxyvitamin D levels (< 20 ng/ml, 20–29 ng/ml and, ≥ 30 ng/ml) and prevalent MetS at baseline and incident MetS at 6 years was examined using logistic regression analysis adjusting for age, gender, race, site, season, education, smoking, alcohol use, physical activity, creatinine, total energy intake (Model 1) plus body mass index (BMI) (Model 2).
Results: At baseline, 998 (38%) participants had prevalent MetS. Compared to vitamin D sufficiency (≥ 30 ng/ml), vitamin D insufficiency (20–29 mg/ml) was associated with a 56% increased odds of prevalent MetS (adjusted OR (95%CI), 1.56 (1.28, 1.91)) and vitamin D deficiency (< 20 ng/ml) was associated with 74% increased odds of prevalent MetS (1.74 (1.39, 2.18)). This association was attenuated after further adjustment for BMI but remained significant (vitamin D insufficiency, 1.36 (1.10, 1.68) and vitamin D deficiency, 1.38 (1.09, 1.76)). Among those without prevalent MetS at baseline that had MetS data at follow up (n=1192), 237 (20%) participants had developed MetS at 6 years. Compared to vitamin D sufficiency, neither vitamin D insufficiency (0.95 (0.66, 1.37)) nor vitamin D deficiency (0.99 (0.65, 1.52)) were associated with incident MetS in a fully adjusted model (Model 2). The results were similar when the analyses were restricted to participants without prevalent diabetes at baseline.
Conclusion:Vitamin D insufficiency and deficiency were associated with a significantly increased odds of prevalent but not incident MetS in this cohort of older adults.
- © 2010 by American Heart Association, Inc.