Abstract 13129: A 4q25 Variant and Cardioembolic Stroke in the Vienna Stroke Registry
Introduction: A single nucleotide polymorphism (SNP) on chromosome 4q25 (rs2200733) was reported to be associated with atrial fibrillation and with ischemic stroke_in particular the cardioembolic stroke (CES) subtype_in genome-wide association studies. We sought to confirm the association of rs2200733 with CES in the Vienna Stroke Registry (VSR) case-control study.
Methods: The genotype of rs2200733 was determined for 189 CES and 487 nonCES cases, and for 733 healthy controls in VSR. The association between rs2200733 and CES or nonCES was assessed by regression models adjusted for traditional risk factors.
Results: rs2200733 was associated with risk of CES: T allele frequency was 14% in controls and 22% in CES cases, with an odds ratio (OR) of 2.13 (95%CI 1.38-3.27) per allele in an additive model. Compared with noncarriers, carriers of one T allele (26% of controls, 32% of cases) had an OR of 1.43 (95%CI 1.01-2.04), and carriers of two T alleles (1.5% of controls, 6% of cases) had an OR of 4.52 (95%CI 1.91-10.7). Adjusting for traditional risk factors did not significantly change the risk estimates. In contrast, rs2200733 T allele frequency was 14% in nonCES cases and was not associated with risk of nonCES (Table).
Conclusions: The association of rs2200733 with cardioembolic stroke was confirmed in the VSR.
- © 2010 by American Heart Association, Inc.