Abstract 13072: A Prospective Study of Sleep Duration and Risk of Incident Stroke in Women
Background: Some recent studies have suggested that shorter sleep duration may be associated with increased risk of diabetes, CHD, and all-cause mortality. Studies linking sleep duration and stroke in women have been limited.
Methods: A total of 69,794 women without history of stroke reported their sleep duration in 1986. Sleep duration categories ranged from 11 hours per night. Incident stroke was ascertained by self-report, review of medical records and death certificates, and search of the National Death Index. During 20 years of follow-up, 2,303 cases of incident stroke were ascertained.
Results: The median sleep duration was 7 hours. Risk of stoke was lowest among women reporting 7 hours of sleep per night and this was used as the referent. Women reporting sleep duration of 6 hours, or < 5 hours/night were not at increased risk of stroke after multivariate adjustment for confounders, including lifestyle factors and depression (Table 1.). However, sleep duration of 10 hours or more was associated with an increased risk of stroke, with a multivariate relative risk (RR) of 1.63 (95% CI, 1.11–2.41). Addition of potential biologic mediators including body mass index, history of hypertension, and history of diabetes to the model modestly attenuated the effect estimates. Results for ischemic stroke were similar, although power was limited for 10 or more hours of sleep.
Conclusion: In this cohort, no increased risk of stroke was observed with short sleep duration, but sleep duration of 10 or more hours was associated with an increased risk of incident stroke.
- © 2010 by American Heart Association, Inc.