Abstract 12709: Decreased Strength of Quadriceps Increases the Risk of Mortality in Patients with Chronic Heart Failure.
Background: Although cardiac cachexia is characterized by an exaggerated loss of skeletal muscle mass and muscle weakness, the diagnostic value of its muscle weakness was still undetermined. The purpose of this study was to investigate the relationship between quadriceps strength and cardiovascular mortality in patients with chronic heart failure (CHF) and to clarify the level of quadriceps strength that indicates a poor prognosis.
Methods: The isometric muscle strength of quadriceps was prospectively measured at the hospital discharge in 90 consecutive CHF patients, 63 males and 27 females aged 67.9 ± 12.6 yrs, which was expressed as % body weight (%BW). Cardiovascular mortality was analyzed with a Cox proportional-hazards models based on cardiovascular risk factors including age, medications, brain natriuretic peptide, estimated glomerular filtration rate and left ventricular ejection fraction.
Results: During the follow-up period of 340±240 days, 9 patients died of cardiovascular events. The relation between quadriceps strength and event free survival rate is shown in Figure. Patients who had lower quadriceps strength had significantly lower survival, and their mortality risk was increased by 2.67-fold per 10 %BW decrease (95% confidence interval: 1.06 to 6.67, P<0.05). Patients with <30%BW of quadriceps strength had a 12.85-fold higher mortality risk as compared with those with ≥40%BW. The two-year mortality rate indicated by quadriceps strength of <30%BW was 51%.
Conclusion: A Quadriceps strength of <30%BW indicated a poor prognosis in patients with CHF.
- © 2010 by American Heart Association, Inc.