Abstract 12521: Cardiovascular Phenotype in Sarcopenic Obesity.
Background: Weight gain occurs over a range of body compositions. Lack of fat-free mass relative to body fat is defined “sarcopenic obesity” and is considered as a potential incremental risk in obesity.
Methods: Therefore, we studied 960 men and 1763 women free of prevalent cardiovascular (CV) disease participants to the 2nd exam of the Strong Heart Study cohort (SHS), to identify CV characteristics associated with sarcopenia. We defined sarcopenia using sex-specific tertiles of the % bioimpedentiometric body fat (%BF). Accordingly, the first tertile of %BF was the reference group (no sarcopenia=NS), the middle tertile was termed moderate sarcopenia (MS) and the highest tertile as severe sarcopenia (SS). The groups were compared using ANCOVA (adjusting for age, sex and BMI) and a linear trend analysis.
Results: %BF was positively related to BMI (r=0.68 in men and r=0.84 in women, both p<0.0001). After adjusting for covariates, systolic and diastolic blood pressure (BP) did not exhibit significant differences between sarcopenic and non-sarcopenic participants, waist circumference progressively increased from NS to SS, paralleling progressive decrease in LV diastolic dimension (3.04; 3.02; 2.98 cm/m, respectively; p<0.001), LV mass, LV mass/height2.7 (41.9; 41.3; 39.6 g/m2.7, respectively; p<0.001), stroke volume (p<0.01), stroke index (26.5; 26.2; 25.6 mL/beat/m2.04; p<0.002), modest decrease in cardiac index (p<0.05) and no difference in relative wall thickness and ejection fraction. Inflammatory markers (CRP and fibrinogen) progressively increased in MS and SS (p<0.0001 and p<0.03, respectively). MDRD-estimated GFR was similar in the three groups. In multiple logistic regression, sex and age-adjusted probability of LV hypertrophy (LVH) increased by 17% each kg/m2 increase in BMI (p<0.0001), but for comparable BMI it decreased by 30% in MS (p<0.02) and by 47% in SS (p<0.0001).
Conclusions: sarcopenic obesity is associated with less probability of LV hypertrophy, independently of age, sex and BMI, and increased levels of inflammatory markers. Further investigations on body composition in obesity are warranted.
- © 2010 by American Heart Association, Inc.