Abstract 12461: Relationship Between Number of Controlled Residual Risk Factors and Incidence of Cardiovascular Events Among Patients Who Achieved Target LDL Cholesterol Level: A Report From the “Heart Care Network” Groups
Background: It is reported that after achieving target LDL cholesterol (LDL-c) level, patients with accumulated residual risk factors (i.e. low HDL cholesterol, high triglyceride, high blood pressure, high blood glucose, and obesity) still have a high incidence rate of cardiovascular (CV) events. However, it remains unknown whether a reduction in the number of such residual factors can affect the incidence of CV events. The Heart Care Network organizes data from 62 sites in Japan with the help of general practitioners treating lifestyle diseases. We examined the relationship between the number of controlled factors and the incidence of CV events among subjects who achieved target LDL-c level using the observational data from this network.
Methods: The Heart Care Network collected data on lifestyle diseases including investigations and medication use during 3-year follow-up period in 14064 high-risk patients (i.e. patients having ≥2 lifestyle risk factors or a history of myocardial infarction). Additionally, incidence of fatal/non-fatal CV events was also recorded. The event-free survival and hazard ratios (HR), after adjusting for age, sex, history of myocardial infarction, smoking, and alcohol intake, and stratified according to the number of controlled risk factors were assessed in subjects who achieved target LDL-c level.
Results: 4033 subjects who achieved target LDL-c level were included in the analysis. Overall, 166 CV events occurred during the follow-up period. Cumulative event-free survival increased and adjusted HR decreased in association with decrease in residual risk factors (Figures).
Conclusions: The management for residual risk factors and reduction in their number in high-risk patients who have achieved target LDL-c level can reduce CV morbidity and mortality.
- © 2010 by American Heart Association, Inc.