Abstract 12242: Epicardial Adipose Tissue Adiponectin Predicts Cardiovascular Prognosis. A Long-term Follow-up Study.
Objective: Epicardial adipose tissue (EAT) produces a wide range of adipokines and has recently been linked to the physiopathology of cardiovascular (CV) and metabolic diseases. We aimed to study whether EAT and subcutaneous (SAT) adiponectin and leptin expression levels are associated with CV outcome during long-term follow-up.
Subjects and methods: We included 120 patients undergoing elective cardiac surgery -mainly for coronary artery bypass grafting (n=69)- between 2004 and 2007. Samples of EAT were collected from 120 patients and SAT from 88 patients. RNA was purified and adiponectin and leptin expression levels analyzed by real time reverse transcription-PCR. Patients were followed up to assess CV events, defined as stroke, coronary acute syndrome, heart failure, need for revascularization or CV death.
Results: Mean age was 70.6 years (s.d. 7.8) and there were 37 women. In all, 28 patients developed CV events during 39.8 (s.d. 23.8) months of mean follow-up. Patients with CV events had lower EAT and SAT adiponectin levels at baseline (12.4 (3.0) vs. 15.2 (3.7) a.u., P<0.001; and 13.7 (2.6) vs. 15.7 (4.5) a.u., P= 0.049, respectively); EAT and SAT leptin levels were not significantly different. Cox proportional hazards models adjusting for covariates in stages revealed that only EAT adiponectin levels (HR 0.898 (0.814–0.990) per a.u., P=0.031), heart failure and diabetes predicted CV events.
Conclusion: EAT adiponectin levels are strong predictors of CV outcomes in patients with CV diseases. EAT can play a major role in the development of CV complications.
- © 2010 by American Heart Association, Inc.