Abstract 12206: Plasma Pentraxin 3 is Associated with Presence of Thin-cap Fibroatheroma in Coronary Culprit Lesion Determined by Optical Coherence Tomography
Backgroud: Vascular inflammation and oxidative stress play key roles in vulnerability of atherosclerotic plaque. Thin-cap fibroatheroma (TCFA) is the primary type of vulnerable plaque. However, inflammatory or oxidative stress markers predicting the presence of in vivo TCFA have not been established. Recently, plasma pentraxin 3 (PTX3) has been shown to be a useful marker for localized vascular inflammation and damage to the cardiovascular system. The aim of this study was to evaluate the association between plasma PTX3 and TCFA as determined by optical coherence tomography (OCT).
Methods: OCT was performed at culprit lesions in 32 patients undergoing percutaneous coronary intervention (stable angina pectoris, n = 22 and acute coronary syndrome, n = 10). Lipid content was semiquantified according to the number of involved quadrants on the cross-sectional OCT image. TCFA was defined as a plaque with lipid contents in ≥2 quadrants and with thinnest part of the fibrous cap measuring <70μm. Plasma PTX3, serum high sensitive C-reactive protein (hsCRP) as inflammatory markers, and plasma 8-isoprostane as an oxidative stress marker were compared between patients with TCFA and without TCFA.
Results: Twelve patients with TCFA and 20 patients without TCFA were identified. PTX3 (10.2 ± 12.4 vs. 2.9 ± 1.5 ng/mL; p = 0.011), hsCRP (30.8 ± 62.6 vs. 1.9 ± 3.1 mg/L; p = 0.004), and 8-isoprostane (15.4 ± 3.3 vs. 13.0 ± 2.1 pg/mL; p = 0.020) were significantly greater in patients with TCFA than without TCFA. PTX3 and hsCRP, but not 8-isoprostane, were inversely correlated with fibrous cap thickness (both r = −0.42, p = 0.039), and only PTX3 was correlated with lipid quadrants (r = 0.39, p = 0.026). In univariate analysis, female, hypercholesterolemia, PTX3, hsCRP, and 8-isoprostane were associated with the presence of TCFA. Multivariate logistic regression analysis in these factors showed that the significant factor related to TCFA existence was PTX3 (OR, 1.68; 95%CI, 1.09 – 2.60; p = 0.020).
Conclusions: High plasma PTX3 level was associated with the presence of TCFA, thinner fibrous cap thickness, and large lipid content in coronary culprit lesions. These findings suggest that plasma PTX3 could be a useful marker associated with in vivo plaque vulnerability.
- © 2010 by American Heart Association, Inc.