Abstract 12185: Time Course of the Restenosis Following Nitinol Stenting in the Superficial Femoral Artery and the Factors Associated with Early and Late Restenosis
Background: Restenosis following nitinol stenting in the superficial femoral artery (SFA) remains unsolved clinical issue. Nonetheless, the time course of the restenosis following nitinol stenting in the SFA remains unclear, while the restenosis following coronary stenting predominantly occurs within the 6 month following stenting. Therefore, we sought to investigate the time course of restenosis and the restenosis factors following nitinol stenting in the SFA.
Methods: We retrospectively analyzed consecutive 585 patients who underwent successful endovascular therapy (EVT) for de novo SFA lesions by provisional nitinol stenting in 742 limbs. Receiver-operating characteristic (ROC) analysis was performed to delineate the time point distinguishing early and late restenosis. No restenosis group was defined as patients with sustained patency; early restenosis group, restenosis occurred before the time point; late restenosis group, restenosis occurred beyond the time point. Restenosis was assessed by duplex ultrasonography. Cox proportional hazard regression analyses were performed to explore the determinants of restenosis in each restenosis group.
Results: Primary and secondary patency was 67% and 86% at 6 years, respectively. ROC curves indicated 369 days after stenting was the best cutoff time point distinguishing early (144 limbs) and late (42 limbs) restenosis. Sustained patency was observed in 556 limbs. After multivariate analysis, use of cilostazol (p=0.0007) was negatively associated; female gender (P=0.0071), diabetes mellitus (p=0.0428), critical limb ischemia (p=0.0435), and stent fracture (P=0.0004) were positively associated with early restenosis, while Smart stent implantation (P=0.0418) was negatively associated with late restenosis. TASC II C/D was positively associated with both early (P=0.0017) and late (P=0.0359) restenoses.
Conclusions: Restenosis predominantly occurred within a year following nitinol stenting in the SFA, and the factors associated with the early restenosis were different from those with the late restenosis.
- © 2010 by American Heart Association, Inc.