Abstract 12078: Lifestyle Factors Associated With Two HDL Subgroups That Divergently Predict Risk of CHD
Background: We recently found that apolipoprotein (apo) CIII influenced the association between HDL and risk of CHD. HDL-cholesterol (C) without apoCIII comprises ∼90% of all HDL-C and is strongly inversely associated with risk of CHD, but HDL-C with apoCIII does not predict a lower risk. We examined if lifestyle characteristics and CVD biomarkers were associated with the two different HDL subgroups.
Methods and Results: HDL-C was measured in plasma separated by presence or absence of apoCIII among 1290 men and women free of CHD at blood draw and who were enrolled in the Nurses' Health and Health Professionals Follow-up Studies. Endogenous and exogenous estrogens were only associated with HDL-C without apoCIII (figure). Compared to postmenopausal women who did not use hormone therapy, premenopausal and postmenopausal women taking hormones had 10.5% higher levels of HDL-C without apoCIII (p= 0.005). Overweight and obesity were associated with 4.5 and 8.3% lower levels of HDL-C without apoCIII (p <0.05), whereas weight was not associated with levels of HDL-C with apoCIII. Current smokers had significantly higher (1.5%) levels of HDL with apoCIII and lower levels of HDL without apoCIII (0.85%) than non-smokers (p<0.001). Alcohol intake was associated with higher levels of both HDL-C types (p<0.05). Interestingly, HDL-C without CIII was inversely associated with plasma triglycerides, but HDL-C with CIII was strongly associated with triglycerides, LDL-C, and HbA1c.
Conclusions: In contrast to HDL-C without apoCIII, HDL with apoCIII is not associated with body weight and estrogens, but is associated with smoking and other atherogenic biomarkers. The different patterns of associations with risk factors for the HDL subgroups provide suggestive evidence that life style factors may modulate the distribution of cholesterol within the two HDL fractions that showed divergent association with risk of CHD in our study populations.
- © 2010 by American Heart Association, Inc.