Abstract 12055: Prevalence of Lipid Abnormalities in the United States: The National Health and Nutrition Examination Survey 2003–2006
Introduction: The association between elevated LDL-C and increased CV risk is well-established, with treatment focusing on LDL-C lowering. Other lipid parameters are also predictive of CV risk, ie, low HDL-C and high TG. Despite national lipid guidelines, prevalence of these abnormal lipid parameters alone or in combination (mixed dyslipidemia) is not well recognized. We assessed prevalence of high LDL-C, low HDL-C, high TG, and mixed dyslipidemia using National Health and Nutrition Examination Survey (NHANES) to determine proportions of US population not at guideline-recommended lipid goals.
Methods: Fasting blood serum data from NHANES 2003–2006 were used to categorize adults aged ≥20 years by their LDL-C, HDL-C, and TG target levels using National Cholesterol Education Program Adult Treatment Panel (ATP III) definitions based on CHD risk. SAS 9.1.2 was used for analyses. Taylor series expansion method was used for variance estimates.
Results: An estimated 53% (105.3M) of US adults have a lipid abnormality; 27% (53.5M) have high LDL-C, 23% (46.4M) low HDL-C, 30% (58.9M) high TG (Figure). Also, 21% (42.0M) of US adults have mixed dyslipidemia, with nearly 6% (11.6M) having all 3 lipid abnormalities. With regard to LDL-C, an estimated 23M adults with CHD or CHD risk equivalent and 10M with ≥2 risk factors (Framingham risk ≤20%) are not at goals of 100 and 130 mg/dL, respectively (Table). Conclusions. The prevalence of dyslipidemia in the US continues to be high, with the majority of US adults now affected by some form of lipid abnormality. Efforts to promote screening, risk stratification, and initiating appropriate treatment should be intensified.
- © 2010 by American Heart Association, Inc.