Abstract 11385: Hypertension in African Americans With Heart Failure: Progression From Hypertrophy to Dilatation; Perhaps Not
Background: Concentric hypertrophy is thought to transition to left ventricular (LV) dilatation and systolic failure in the presence of long standing hypertension (HTN). Whether or not this transition routinely occurs in humans is unknown.
Methods: We consecutively enrolled African American patients hospitalized for acute decompensated volume overload heart failure (HF). All patients had a history of HTN and absence of obstructive coronary disease. Patients were divided into those with normal left ventricular ejection fraction (LVEF) and reduced LVEF. LV dimensions were measured according to standard ASE recommendations. LV mass was calculated using the ASE formula with Devereux correction.
Results: Demographic, clinical and echocardiographic results are listed in Table 1. Patients with reduced LVEF HF were significantly younger, male, had a higher GFR, and had a shorter duration of HTN with lower systolic blood pressure on admission. LV wall thickness was similarly elevated in both groups. LV mass was elevated in both groups however was significantly greater in the reduced LVEF HF group compared to the normal LVEF HF group.
Conclusion: In African American patients with HF, our study questions the paradigm that concentric hypertrophy transitions to LV dilatation and systolic failure in the presence of HTN. Genetics and gender likely play a role in an individual's response to long standing hypertension.
- © 2010 by American Heart Association, Inc.