Abstract 11362: Relationship of Blood Pressure With Coronary Artery Calcium Progression in the Multi-Ethnic Study of Atherosclerosis
Background: A history of hypertension (HTN) is an independent risk factor for CHD events and underlying coronary atherosclerosis. The purpose of this study was to determine whether different measures of systolic and diastolic blood pressure as well as pulse pressure and mean arterial pressure are associated with incident CAC among those with absent CAC at baseline as well as progression of CAC scores among those with CAC>0 at baseline exam, respectively
Methods: MESA is a prospective cohort study of 6814 participants free of clinical cardiovascular disease at entry who underwent risk factor assessment and CAC testing at baseline (exam 1) and follow up (exam 2–4) examinations. We assessed 1) incident CAC, defined as detectable CAC at the follow-up exams among those free of CAC at baseline, and 2) absolute CAC score change among those with detectable CAC at baseline. The independent relation between increasing HTN and blood pressure (BP) variables (per SD increase) with CAC progression was assessed by relative risk (RR) regression (for incident CAC) using a generalized linear model and binomial error distribution adjusting for covariates. We excluded 767 individuals who did not undergo follow-up CAC testing.
Results: The final study population consisted of 6047 individuals (62±10 years, 48= males). During a mean follow-up period of 3.1±1.3 years, among 3100 (51=) individuals with no detectable CAC at baseline, 20% (n=622) developed CAC. Table 1 demonstrates that in demographic and traditional risk factors adjusted analyses, the presence of HTN and higher BP levels were significantly associated with incident CAC and with progression of absolute CAC scores among those with CAC>0 at baseline.
Conclusions: Presence of HTN and BP levels were associated with the initial occurrence of coronary arterial calcification in individuals with no calcium deposition at baseline as well as with CAC progression in individuals with a positive calcium score at baseline.
- © 2010 by American Heart Association, Inc.