Abstract 11319: Smoking and Smoking Cessation in Relation to All-cause Mortality, Stroke, Ischemic Heart Disease, and Total Cardiovascular Events in Young- and Middle-aged Japanese Men
Background Data regarding associations among smoking, smoking cessation, mortality, and cardiovascular disease (CVD) is still inadequate in young- and middle-aged Asians.
Methods and Results A total of 25,464 healthy Japanese men aged 20–61 years and not on any medication were followed over 7.6 years. For moderate and heavy smokers, the adjusted hazard ratios for stroke were 2.52 (1.30, 5.36) and 2.19 (0.96, 5.14), and those for total CVD events, which included both stroke and any other cardiovascular events, were 2.87 (1.62, 5.50) and 3.19 (1.66, 6.41), respectively. In contrast, the hazard ratios (95% confidence interval) for myocardial infarction, adjusted for age, systolic blood pressure, total cholesterol and fasting plasma glucose, were 6.09 (1.49, 29.6), 3.59 (1.18, 15.5), and 5.42 (1.69, 24.0) for light smokers (1–10 cigarettes/day), moderate smokers (11–20/day), and heavy smokers (≥21/day) compared to never-smokers, respectively. However, quitters showed significant low CVD event rates: the adjusted hazard ratios of ≥ 4 years quitter were 0.57 (0.34, 0.91) for death, and 0.27 (0.13, 0.50) for total CVD events, and quitters who had used to smoke less than 10 cigarettes tended to have lower CVD event rates than those who smoked 11 cigarettes per day or more.
Conclusions Moderate to heavy smoking were significantly associated with stroke in young- and middle-aged Japanese men. In contrast, even light smoking was significantly associated with myocardial infarction. Quitters for ≥4 years showed significant low risk of death and total CVD events
- © 2010 by American Heart Association, Inc.