Abstract 11306: Heart Failure Associated with Neural Injury in a Critical Area for Planning
A significant issue in heart failure (HF) is diminished cognitive function, including memory, learning, and planning deficits. A basal ganglia structure, the putamen, serves many of these memory and planning functions. However, the status of putamen structural integrity in HF is unknown.
Methods: We collected two high-resolution T1-weighted structural scans from 17 HF subjects (age 54.4±8.1 years; BMI 29.4±5.7 kg/m2; LVEF 0.28±0.07; 7 ischemic etiology; 12 male) and 50 controls (age 50.5±7.3 years; BMI 24.7±4.0 kg/m2; 28 male) using a 3.0 Tesla magnetic resonance imaging scanner. Both T1-weighted volumes were realigned, averaged to improve signal-to-noise, and reoriented (without warping) into a common space. Using these averaged and reoriented images, the bilateral putamen were manually-outlined and volumes calculated. Demographic data between groups were compared with independent samples t-tests and Chi-square, and both putamen volumes between HF and control groups were evaluated using ANCOVA, with age, gender, and total intracranial volume included as covariates.
Results: No significant differences in age (p = 0.07) or gender (p = 0.29) appeared between HF and control groups. BMI was greater in the HF group (HF subjects heavier; p = 0.005). HF patients showed significantly reduced left putamen volumes (HF vs controls; 3547.3±622.2 mm3 vs 3899.2±461.8 mm3, p = 0.02); the right side structures only trended to volume reduction (3611.4±561.0 mm3 vs 3850.4±486.9 mm3, p = 0.12).
Conclusions: Left putamen volumes are reduced in HF compared to control subjects, and may contribute to memory, planning, and learning deficits found in the syndrome. The precise pathological mechanisms contributing to the volume loss are unclear, but may develop from hypoxic or ischemic processes, secondary to low cardiac output or sleep-disordered breathing, common in the syndrome.
- © 2010 by American Heart Association, Inc.