Abstract 11187: Prognostic Implications of Low-Level Elevations of Ultrasensitive Troponin: Two-Year Follow-Up
Introduction: Hospitalized patients frequently have low-level elevations in ultrasensitive troponin (UST), which are often associated with elevated serum creatinine and/or BNP. Clinicians must decide whether this low-level elevation carries prognostic significance to warrant more aggressive work-up and therapies.
Hypothesis: We hypothesized that hospitalized patients with low-level UST elevations (0.06–0.09 ng/ml), with and without concomitant elevations in BNP (≥100) and serum creatinine (≥1.5), would have worse prognosis at 2 years compared to those with negative UST.
Methods: Data was collected on 6328 consecutive patients admitted to hospital from Feb. 2007 to Feb. 2008 who had UST levels checked; 2809 patients had at least one elevated troponin during hospitalization, and 3519 patients had only negative UST. Patients with peak UST ≥ 0.1 ng/ml were excluded. Social Security Death Master File was used to determine 2-year mortality. Multivariate logistic regression analysis obtained adjusted odds ratios (OR) to evaluate risk of UST, BNP and creatinine elevations, while adjusting for age and gender differences between the groups.
Results: See Figures 1 and 2.
Conclusions: Low-level UST elevation in hospitalized patients imparts a significantly worse prognosis at two years, especially if BNP level is ≥100, even when there is concomitant elevated creatinine.
- © 2010 by American Heart Association, Inc.