Abstract 11096: Clinical Validation of High Sensitive Cardiac Troponin T in Heart Failure: Comparison with N-terminal Pro-B-type Natriuretic Peptide and Echocardiographic Parameters
Introduction: Circulating cardiac troponin T is a marker of cardiomyocyte injury, and predicts adverse outcomes in patients with chronic heart failure. However, the significance of high sensitive cardiac troponin T (hs-TnT) in cardiac dysfunction remains uncertain. The purpose of this study is therefore to evaluate the correlation between hs-TnT and N-terminal pro-B-type natriuretic peptide (NT-proBNP) or echocardiographic parameters in patients with heart failure.
Hypothesis: Minor and ongoing myocardial damage may be detected by hs-TnT in heart failure and hs-TnT levels may correlate with NT-proBNP levels or cardiac dysfunction evaluated by echocardiography.
Methods: Two hundred twenty-five patients who were suspected heart failure and examined by echocardiography were enrolled (124 males, mean age: 63.1 years old). Left ventricular ejection fraction (LVEF), E/E′, and right and left ventricle Tei index were determined with echocardiography. Serum levels of hs-TnT, NT-proBNP and creatinine were measured simultaneously. The estimated glomerular filtration rate (eGFR) was calculated by the equation of the Japanese Society of Nephrology.
Results: The linear regression analyses demonstrated that hs-TnT levels closely correlated with NT-proBNP levels (r=0.739, p<0.0001, Figure) and eGFR (r=0.554, p<0.0001). By multiple variable regression analyses, NT-proBNP and eGFR were independently correlated with hs-TnT. Furthermore, hs-TnT levels significantly correlated with right ventricle Tei index (r=0.413, p<0.0001), left ventricle Tei index (r=0.335, p<0.0001), LVEF (r=0.341, p<0.0001) and E/E′ (r=0.464, p<0.0001).
Conclusions: The hs-TnT levels correlated with cardiac dysfunction evaluated by neurohormonal factor and echocardiography. Minor and ongoing myocardial injury in heart failure may be detected by hs-TnT.
- © 2010 by American Heart Association, Inc.