Abstract 10954: Sex-Based Differences in the Risk Factor Profiles and Outcomes of Japanese Patients Undergoing Percutaneous Coronary Intervention
Background: Limited data are available for sex-based differences in patients undergoing percutaneous coronary interventions (PCI) in Asian populations. This study aimed to identify sex-based differences in the risk factor profiles and outcomes of Japanese patients undergoing PCI.
Methods and Results: The study subjects consisted of 6,740 patients (2,005 women and 4,735 men) who underwent first PCI in 2000–2002 in 30 Japanese institutions. The clinical characteristics, treatments and outcomes were compared between women and men. Major adverse cardiovascular events (MACE) were defined as the composite of cardiovascular death, and non-fatal myocardial infarction and stroke. Women were 5 years older than men and more frequently had history of heart failure, diabetes, hypertension, dyslipidemia, chronic kidney disease and anemia. Unadjusted survival analyses revealed that the incidence of any coronary revascularization was significantly lower in women than in men with 3-year incidence of 35.7% and 40.6%, respectively (p<0.001, Figure). A Cox proportional hazard model adjusted for baseline characteristics also indicated lower incidence of any coronary revascularization in women (relative risk=0.91, 95% CI=0.86–0.97, p=0.002). The significantly lower incidence in women was seen both in target lesion revascularization (TLR)-PCI and in non-TLR-PCI. Although there were no significant differences between women and men in unadjusted incidence of all-cause death (8.0% versus 7.7% at 3-year, p=0.62) and MACE (11.1% versus 10.3% at 3-year, p=0.61), baseline characteristics adjustment revealed the lower risk of all-cause death in women (relative risk=0.82, 95% CI=0.72–0.95, p=0.006).
Conclusions: In Japanese patients undergoing first PCI, the coronary risk factor burden appeared greater in women than in men. Female sex appeared to confer better outcomes regarding repeated coronary revascularization and mortality.
- © 2010 by American Heart Association, Inc.