Abstract 10953: Hypoglycaemia is Associated to Co-Morbid Vascular Disease in Type-2 Diabetic Patients on Oral Antidiabetic Therapy - An Analysis of the Diaregis Registry
Background: Patients with type-2 diabetes are at risk for treatment and disease related complications. Little is known about the interrelation of glycaemic control, hypoglycaemia and co-morbid vascular disease (VD; coronary heart disease, stroke and peripheral arterial disease). Hypothesis: Hypoglycaemia is associated with co-morbid VD in diabetic patients.
Methods: DiaRegis is a prospective registry including 3,988 patients with type-2 diabetes in 2009/2010. Metric variables are displayed as median and quartiles. For the comparison of patients with or without VD Odds Ratios (OR) were determined from univariate analyses and adjusted for differences in patient characteristics (multivariable analysis).
Results: For 3,750 patients (94.0%) data on hypoglycaemia were available. Median (IQR) age was 66.1 (57.7–72.9) years, 46.6% were female. VD patients (n=904; 24.1%) were older (70.6 vs. 64.1 years; p<0.0001), less female (33.2% vs. 50.9%; p<0.0001) and had longer diabetes duration (6.5 vs. 5.4 years; p<0.0001). Mean cholesterol (Total, HDL and LDL-C) was slightly lower (p<0.0001). Glycaemic control (HbA1c, fasting and postprandial glucose) was comparable. VD patients received less metformin (81.8 vs. 85.5%; p<0.01) and more sulfonylureas (34.0 vs. 28.6%; p<0.01). There was an increased incidence of symptomatic hypoglycaemia requiring help (OR 2.81; 95%CI 1.40–5.64) and with a need for medical assistance (OR 5.07; 95%CI 1.65–15.54). After adjusting for age, gender, smoking, heart failure, amputation, depression, metformin, sulfonylureas and HbA1c, the symptomatic hypoglycaemias with help in patients with VD remained significantly increased (OR 3.70, 95% CI 1.55–8.84).
Conclusions: At comparable glycaemic control, patients with vascular disease reported to have experienced more episodes of hypoglycaemia requiring help or even medical assistance than patients without vascular disease.
- © 2010 by American Heart Association, Inc.