Abstract 10906: Fructose Containing Sugars do Not Result in an Atherogenic Lipid Profile When Consumed as Part of a Eucaloric (Weight-Stable) Diet
Introduction: Sucrose and high fructose corn syrup (HFCS) are the primary sources of fructose in the American diet. It has been postulated that excess fructose consumption may be atherogenic. The American Heart Association (AHA) has advocated that women and men not consume more than 100 and 150 kcal/day, respectively, from added sugars. These levels are currently exceeded by over 90% of the adult population in the United States. Acute studies have shown sucrose and HFCS to have equivalent metabolic effects for every parameter yet measured in humans, but few data exist on longer-term metabolic effects when these two sugars are consumed at levels typical of the general population.
Methods: Sixty-four overweight and obese individuals (38.3 ± 11.9 years) were placed on a eucaloric (weight-stable) diet for 10 weeks, which incorporated sucrose- or HFCS-sweetened, low-fat milk at 10% or 20% of calories (25th and 75th percentile for adult fructose consumption levels). This was a double-blind study, and at the time of the current analysis the blind had not yet been broken.
Results: All groups responded similarly (interaction p>0.05). There was no change in body weight in the entire cohort (179.38 ± 35.23 vs 180.60 ± 35.51 lbs, p>0.05) over the 10 week study. Likewise, there were no changes in total cholesterol (184.86 ± 40.01 vs 185.56 ± 39.41 mg/dl), triglycerides (133.64 ± 73.29 vs 135.06 ± 77.44 mg/dl), LDL (106.94 ± 36.67 vs 108.75 ± 35.44 mg/dl), Apo B (94.36 ± 23.80 vs 93.72 ± 25.09 mg/dl) and mean LDL particle size (266.93 ± 5.05 Å vs 266.71 ± 5.47 Å). Furthermore, group assignment had no affect on HDL (interaction p>0.05). Of note, all of these values are within established population norms.
Discussion: The absence of any statistically significant differences between the two groups suggests that 1) when consumed as part of a eucaloric (weight-stable) diet, fructose does not promote weight gain or an atherogenic lipid profile even when consumed at four times the level currently recommended by the AHA; and 2) there are no differences between sucrose and HFCS in these measures at typical levels of sweetener consumption.
- © 2010 by American Heart Association, Inc.