Abstract 10904: Resting Heart Rate and Coronary Artery Calcium in Postmenopausal Women
Background: Resting heart rate (RHR) is a marker of autonomic nervous system activity and has been shown to be a significant predictor of future cardiovascular disease (CVD) morbidity and mortality. Coronary artery calcium (CAC) is a surrogate marker of the presence and extent of atherosclerotic coronary artery disease and is strongly associated with incident CVD independent of traditional risk factors.
Methods: Using data from the Women's Health Initiative (WHI), this study examined the association between RHR and CAC in 998 postmenopausal women between the ages of 50 and 59 at enrollment. RHR was measured at enrollment and throughout the course of the study while CAC was determined approximately 7 years after the baseline clinic visit.
Results: The mean (SD) age was 55 (2.8) years. With adjustment for age and ethnicity, a 10-unit increment in RHR was significantly associated with CAC (1.18, 1.01 – 1.38), but this was no longer significant after adjustment for body mass index, income, education, dyslipidemia, diabetes, smoking and hypertension (1.06, 0.90 – 1.25). However, in a fully adjusted multivariable model, there was a significant interaction (p = 0.03) between baseline RHR and systolic blood pressure (SBP) for the presence of any CAC (Figure). Specifically, compared to those with a RHR < 80 beats per minute and an SBP < 140 mmHg, those who had RHR ≥ 80 beats per minute and an SBP ≥ 140 mmHg had a 2.66-fold higher odds (1.08 – 6.57) for the presence of any CAC.
Conclusions: Individuals with an elevated systolic blood pressure and RHR have a significantly higher odds for the presence of calcified coronary artery disease.
- © 2010 by American Heart Association, Inc.