Abstract 10882: The Associations of Plasma Phospholipid Omega-6 and Omega-3 Fatty Acid Levels and Cardiac Magnetic Resonance Imaging Measures of Left Ventricular Structure and Function: The Multi-Ethnic Study of Atherosclerosis
Background: The association between plasma phospholipid omega-6 levels and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid (ALA).
Objectives: To determine the associations between plasma phospholipid omega-6 levels (arachidonic acid (AA), linoleic acid (LA)) and plasma phospholipid omega-3 levels (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), ALA) with cardiac magnetic resonance imaging (CMR) measures of left ventricular (LV) structure and function.
Design: Associations of plasma phospholipid levels with CMR measures of aortic distensibility, LV mass, LV volumes, ejection fraction and stroke volume were investigated within a subset of 1,274 adults of mixed racial/ethnic groups, aged 45–84 years, free of clinical CVD who underwent CMR during baseline assessment.
Results: Multivariate analysis adjusted for age, race/ethnicity, gender, BMI, smoking, education, physical activity, systolic blood pressure, total:HDL cholesterol, total energy intake, and alcohol intake, demonstrated an inverse association between plasma phospholipid LA and ejection fraction, with the highest quartile of LA corresponding with a 1.99% lower ejection fraction compared to the lowest LA quartile (p = 0.007). We found no significant associations between plasma phospholipid omega-3 levels and CMR measures in multivariate-adjusted analyses. When stratified by sex, plasma phospholipid DHA was positively associated with LV mass in women (β = 1.948 for women, β = −0.097 for men; p for interaction = 0.003), and plasma phospholipid DHA was positively associated with ejection fraction in men (β = 0.011 for men, β = −0.0001 for women; p for interaction = 0.01).
Conclusions: Within this cohort of mixed racial/ethnic groups without clinical CVD, an inverse association between plasma phospholipid LA and ejection fraction was observed. The association of plasma phospholipid DHA with LV mass and ejection fraction differed by sex. These data suggest that more research is warranted to clarify the effects of omega-3 omega-6 phospholipid levels on cardiac structure and function.
- © 2010 by American Heart Association, Inc.